Mycobacterium Tuberculosis and Hepatitis Co-Infection in Dialysis Patients: Synergic Immune Dysregulation Leading to Disease Progression
نویسندگان
چکیده
Patients with end stage renal disease (ESRD) ongoing hemodialysis treatment (HD) have more than 10 [6-16] fold increased risk for development of tuberculosis (TB). The tuberculin reaction is sometimes negative; this may be due to an overwhelming infection impairing the immune response. Tuberculous cervical lymphadenitis is the commonest form of nonrespiratory TB. We report herein three dialysis patients; two of them had extrapulmonary TB, such as tuberculous lymphadenitis and had hepatitis C virus (HCV) or hepatitis B virus (HBV) infection together. Finally, it was considered that ESRD, dialysis and HCV or HBV infection might reduce the effectiveness of the body's immune system, which can allow dormant bacteria to become reactivated.
منابع مشابه
مقایسه ی سطح سرمی α-TNF، اینترلوکین-10، اینترلوکین-12 و اینترفرون گاما در بیماری های ناشی از مایکوباکتریوم های توبرکلوزیس و غیرتوبرکلوزیس
Introduction: Determination of produced cytokines, especially interleukin 10, interleukin 12, interferon gamma and TNF-α is an important tool in the review of safety responses against inducers such as illnesses. The purpose of this study was to investigate the immune system status in patients with mycobacterium infections such as tuberculosis and non-tuberculosis as compared to healthy controls...
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Historically, tuberculosis has been the leading cause of death throughout human history. Tuberculosis infection (TB) causes by Mycobacterium tuberculosis that is very dangerous and can affect any parts of the body, especially lungs. Tuberculosis infection still remains a serious threat to human public health due to its contagious nature, capability to stay latent form in host for indefinite tim...
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